姓名：王秋文
职称职务：特聘教授、博导
电子邮箱：qwwang@suda.edu.cn
办公地址：苏州大学国际创新药学院509-2
个人简介
王秋文博士，国际创新药学院教授，博士生导师，课题组长。本科毕业于山东师范大学，博士毕业于清华大学，期间与哈佛大学医学院联合培养，2025年回国前为美国加州索尔克生物研究所博士后研究员。在国际知名期刊发表13篇SCI论文，引用一千余次。其中以第一作者或共同第一作者在Nature Neuroscience (IF 25.7)、Nature (IF 54.4)、PNAS (IF 10.8)、Cell Reports (IF 7.5)等国际主流期刊发表多篇论文；获得了5项发明专利授权，其中包括4项国际专利，1项中国专利。主要从神经系统疾病、大脑类器官和衰老研究。
研究方向
1. 衰老相关的神经退行性疾病的病理研究
2. 新型类器官开发与干细胞治疗
3. 双相情感障碍的致病机理研究
4. 神经系统疾病新型药物开发
代表性论文（*代表第一作者）
1. Yaonan Liu*, Qiuwen Wang*, Xinyu She*, Lijun Li*, Bing Wang, Ruilan Yang, Qian Li, Siyao Lu, Yinghan Wang, Wei Shen, Chonglei Fu, Lan Yi1, Chunxue Wang, Wei Shi, Xin Cheng, Liping Cao, Shuangli Mi, and Jun Yao. A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nature Neuroscience 2025. https://doi.org/10.1038/s41593-025-02040-y.
2. Yaonan Liu, Qiuwen Wang, Siyao Lu, Wei Shen, Chongye Guo, Zhikai Xing, Chang Li, Shan Sun, Senfang Sui, Shuangli Mi, Fred H Gage, Jun Yao. Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice. iScience 2025. https://doi.org/10.1016/j.isci.2025.112354.
3. Qiuwen Wang*, Junhong Qin*, Yanfen Chen*, Yingfeng Tu*, Yunyun Xing, Yuchen Wang, Lvyu Yang, Siyao Lu, Libo Geng, Wei Shi, Yiming Yang, Jun Yao. 16p11.2 CNV gene Doc2α contributes to neurodevelopment and social/repetitive behaviors through interacting with Secretagogin. Cell Reports 2023. doi: 10.1016/j.celrep.2023.112691.
4. Qiuwen Wang*, Yinghan Wang, Bing Wang, Yun Chen, Siyao Lu, Jun Yao. Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants. PLOS Biology. 2021. doi:org/ 10.1371/journal.pbio.3001323.
5. Siyao Lu, Chonglei Fu, Liang L, Bo Yang, Wei Shen, Qiuwen Wang, Yun Chen, Yanfen Chen, Yaonan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, and Jun Yao. miR-218-2 regulates cognitive functions in the hippocampus through C3-dependent modulation of synaptic vesicle release. PNAS 2021. doi:10.1073/pnas.2021770118.
6. Yun Chen, Yinghan Wang, Yi Zheng, Meijing Li, Bing Wang, Qiuwen Wang, Chonglei Fu, Yaonan Liu, Xueming Li, Jun Yao. Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons. Cell Reports 2021. doi: 10.1016/j.celrep.2021.108842.
7. Qiuwen Wang*, Siyao Lu*, Yaonan Liu*, Yun Chen, Hui Wei, Wei Shen, Yanfen Chen, Chonglei Fu, Yinghan Wang, Anbang Dai, Xuan Huang, Fred H. Gage, Qi Xu, and Jun Yao. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. PNAS 2020. doi:10.1073/pnas.2016416117.
8. Wei Shen*, Qiuwen Wang*, Yao-nan Liu*, Maria C. Marchetto, Sara Linker, Si-yao Lu, Yun Chen, Chuihong Liu, Chong-ye Guo, Zhikai Xing, Wei Shi, John R. Kelsoe, Martin Alda, Hongwei Wang, Yi Zhong, Sen-Fang Sui, Mei Zhao, Yiming Yang, Shuangli Mi, Liping Cao, Fred H. Gage, and Jun Yao. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. PNAS 2020. doi: 10.1073/pnas.1918165117.
9. Xuan Huang, Shan Sun, Xiaojing Wang, Fenghui Fan, Qiang Zhou, Shan Lu, Yong Cao, Qiuwen Wang, Mengqiu Dong, Jun Yao, Sengfang Sui. Mechanistic insights into the SNARE complex disassembly. Science Advances 2019. doi: 10.1126/ sciadv.aau 8164.
10. S Stern, R Santos, M C Marchetto, A P D Mendes, G A Rouleau, S Biesmans, Qiuwen Wang, J Yao, P Charnay, A G Bang, M Alda and, Fred H Gage. Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. Molecular Psychiatry 2018. doi: 10.1038/mp.2016.260.
11. Mertens J*, Qiuwen Wang*, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, PBDS, Mi S, Brennand KJ, Kelsoe JR, Fred H Gage, Jun Yao. Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature 2015. doi:10.1038/nature15526.