姓 名：徐聪聪
职称职务：青年特聘教授
电子邮箱：xucc@suda.edu.cn
联系电话：13262231356
个人简介：
徐聪聪，博士，苏州大学国际创新药学院青年特聘教授，上海市白玉兰计划浦江人才。湖南大学化学学士学位，俄亥俄州立大学药学院获药剂科学博士学位（导师：郭培宣教授），2020-2023年于mRNA头部企业担任mRNA平台研发负责人，2023年受聘为苏州大学国际创新药学院青年特聘教授。现主持一项上海市科技创新行动计划项目及苏州大学高层次人才科研启动项目，以共同作者在Nature, ACS Nano, Molecular Therapy等国际期刊发表多篇论文，获得国际专利授权两项，主要研究方向为新型RNA疫苗和药物。
研究方向：
基于RNA平台技术的新型疫苗和创新药物的发现及工程化改造研究：
Ø 新型RNA平台包括自复制型mRNA以及环状RNA的开发及设计
Ø mRNA肿瘤疫苗和传染病疫苗的开发和机制探究
Ø 人工智能算法指导的mRNA序列优化及设计
Ø 核酸疫苗及药物的递送系统开发和探索
代表性论文：
1. Xu, C., Zhang, L., Wang, W., Tang, Y., Wang, Q., An, J., ... & Li, H. (2023). Improving the Circularization Efficiency, Stability and Translatability of Circular RNA by circDesign. bioRxiv, 2023-07.
2. Zhang, H. †, Zhang, L. †, Lin, A. †,Xu, C. † (co-first author), Li, Z., Liu, K., ... & Huang, L. (2023). Algorithm for optimized mRNA design improves stability and immunogenicity. Nature, 1-3.
3. Fang, Y., Li, J.X., Duangdany, D., Li, Y., Guo, X.L., Phamisith, C., Yu, B., Shen, M.Y., Luo, B., Wang, Y.Z., Liu, S.J., Zhao, F.F., Xu, C., Qiu, X.H., Yan, R., Gui, Y.Z., and Mayxay, Mayfong. et al 2024. Safety, immunogenicity, and efficacy of a modified COVID-19 mRNA vaccine, SW-BIC-213, in healthy people aged 18 years and above: a phase 3 double-blinded, randomized, parallel controlled clinical trial in Lao PDR (Laos). eClinicalMedicine, 67.
4. Carcache PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P. Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes. RNA. 2021 Sep 1;27(9):971-80.
5. Guo S., Xu C., Yin H., Hill J., Pi F., Guo P. (2019). Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation. WIREs Nanomedicine and Nanobiotechnology, 2019 Aug 27:e1582. doi: 10.1002/wnan.1582
6. Xu, C., Zhang, K., Yin, H., Li, Z., Krasnoslobodtsev, A., Zheng, Z., Ji, Z., Guo, S., Li, S., Chiu, W. and Guo, P.,2020. 3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution. Nano Research, 13(12), pp.3241-3247.
7. Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P. RNA nanoparticles as rubber for compelling vessel extravasation to enhance tumor targeting and for fast renal excretion to reduce toxicity. ACS Nano. 2020 Sep 9;14(10):13180-91.
8. Zheng Z, Li Z, Xu C, Guo B, Guo P. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J Control Release. 2019Aug22;. doi: 10.1016/j.jconrel.2019.08.021.
9. Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA NanoparticlesTargetingStem Cell Marker CD133. Mol Ther. 2019 Jul 3;27(7):1252-1261. doi: 10.1016/j.ymthe.2019.04.018.
10. Xu Y, Pang L, Wang H, Xu C, Shah H, Guo P, Shu D, Qian SY. Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression. Redox Biol. 2019 Feb;21:101085. doi: 10.1016/j.redox.2018.101085.
11. Xu C, Li H, Zhang K, Binzel DW, Yin H, Chiu W, Guo P. Photo-controlled release of paclitaxel and model drugs from RNA pyramids. Nano Res. 2019 Jan;12(1):41-48. doi: 10.1007/s12274-018-2174-x.
12. Xu C, Haque F, Jasinski DL, Binzel DW, Shu D, Guo P. Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy. Cancer Lett. 2018 Feb 1;414:57-70. doi: 10.1016/j.canlet.2017.09.043.
13. Haque F†, Xu C†, Jasinski DL, Li H, Guo P. († Contributed equally) Using Planar Phi29 pRNA Three-Way Junction to Control Size and Shape of RNA Nanoparticles for Biodistribution Profiling in Mice. Methods Mol Biol. 2017;1632:359-380. doi: 10.1007/978-1-4939-7138-1_23.
14. Guo S, Xu C, Yin H, Guo P, Hill J, and Pi F. 2022. Tuning theSize,Shape, andStructureof RNA Nanoparticles forFavorableCancerTargetingand Immunostimulation. RNA Nanotechnology and Therapeutics, pp.543-562.