尤祎
心血管病研究所
苏州大学优秀青年学者
中国病理生理学会会员
E-mail：youyi@suda.edu.cn
个人简介
尤祎博士毕业于北京大学化学基因组学专业；主要研究方向为工程化外泌体, 核酸类药物靶向递送，心脏类器官构建与应用，罕见病基因与细胞治疗等；研究成果以第一和共同作者在Nature biomedical engineering，European Heart Journal，J Extracell Vesicles等国内外期刊发表SCI论文9篇；开发外泌体载体的“first in class” 核酸类药物（SPOT-001注射液）获得IIT临床申报批准并吸引IDG资本、尚珹资本等机构超3000万美元的A轮融资。主持国家自然科学基金青年项目，国家干细胞，苏州市科协青年托举工程等项目。申请和授权国家发明专利2项；国际专利1项。担任Organoid Research期刊青年编委。
论文成果：
[研究论文，# 共同第一作者，*共同通讯作者]
1. You Y#, Tian Y#, Guo R, Shi J, Kwak KJ, Tong Y, Estania AP, Hsu WH, Liu Y, Hu S, Cao J, Yang L, Bai R, Huang P, Lee LJ, Jiang W, Kim BYS, Ma S, Liu X, Shen Z*, Lan F*, Phuong Nguyen PK*, Lee AS*. Extracellular vesicle-mediated VEGF-A mRNA delivery rescues ischaemic injury with low immunogenicity. Eur Heart J. 2025 May 2;46(17):1662-1676. (心血管顶刊, IF: 35.6）
2. You Y#, Tian Y#, Yang Z#, Shi J, Kwak KJ, Tong Y, Estania AP, Cao J, Hsu WH, Liu Y, Chiang CL, Schrank BR, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup TD, Ha J, Dong S, Li X, Wang Y, Lu WJ, Bahrani E, Lee LJ, Teng L, Jiang W, Lan F*, Kim BYS*, Lee AS*. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nat Biomed Eng. 2023 Jul;7(7):887-900. (生物医学工程顶刊, IF: 26.8）
3. Yan Y, You Y#, Ma S, Yi H, Chen G, Ni J, Chen C, Ke W, Li L, Bai R, Ran Y, Lu W, Zhu M, Zhang Y, Dai J, Qi M, Lan F, Lee AS, Zhang R, Liu X, Chen Z. Efficient Scaling up EV-AAVs Production via Cellular Nanoporation for Familial Hypercholesterolaemia Therapy. J Extracell Vesicles. 2025 Nov;14(11):e70186. doi: 10.1002/jev2.70186. PMID: 41216903; PMCID: PMC12603781.(中科院一区, IF: 14.48)
4. Bai R, Zhang S, Gu X, You Y*, Liu X*. Establishment of a TRPV2 knockout human embryonic stem cell line (WAe009-A-1Y) using episomal vector-based CRISPR/Cas9. Stem Cell Res. 2025 Sep; 87:103744. doi: 10.1016/j.scr.2025.103744. Epub 2025 May 30. PMID: 40483902.
5. Cao Y#, You Y#, Wang Q#, Ren X, Li S, Li L, Xia W, Guan X, Yang T, Ikegawa S, Wang Z, Zhao X*. Identification of six novel variants from nine Chinese families with hypophosphatemic rickets. BMC Med Genomics. 2022 Jul 16;15(1):161. (IF: 2.0)。
6. Li S#, You Y#, Gao J, Mao B, Cao Y, Zhao X*, Zhang X*. Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families. BMC Med Genet. 2018 Oct 3;19(1):179. BMC medical genetics, 2018, 19: 1-11.
7. You Y#, Wang X#, Li S, Zhao X*, Zhang X*. Exome sequencing reveals a novel MFN2 missense mutation in a Chinese family with Charcot-Marie-Tooth type 2A. Exp Ther Med. 2018 Sep;16(3):2281-2286. (IF: 2.3)
8. Mao B#, Zhang J#, You Y#, Xiao J, Zhao X*. Mutations in the highly conserved 1A rod domain of keratin 9 responsible for epidermolytic palmoplantar keratoderma in four Chinese families. J Dermatol. 2018 Feb;45(2):e45-e46. (IF: 2.7)
9. Ma Z#, Li M#, Guo R#, Tian Y#, Zheng Y, Huang B, You Y, Xu Q, Cui M, Shen L, Lan F, Yang H, Liu R, Yang T, Wan F, He Q, Huo X, Bi Y, Zhang Y*, Ling Y*. Treating myocardial infarction via a nano-ultrasonic contrast agent-mediated high-efficiency drug delivery system targeting macrophages. Sci Adv. 2025 Jan 3;11(1):eadp7126(IF: 12.5)