王艺璇
主管药师
苏州大学附属第四医院GCP药师
E-mail：yxwang111@suda.edu.cn
个人简介
王艺璇，南京大学药理学博士，现为讲师，主管药师。主要从事抗炎免疫药理学与抗肿瘤药理学研究。主持国家自然科学基金青年基金项目(C类)1项、江苏省自然科学基金青年项目1项、苏州市科技局项目1项。在Oncogene、Br J Pharmacol、Acta Pharmacol Sin等药理学经典期刊发表多篇文章。
研究方向
1. 银屑病等炎症性疾病发病机制及药物靶标研究
2. 肿瘤发生发展机制及靶标挖掘
3. 抗肿瘤药物经济学研究
代表性论文（*代表通讯作者）
1.Yixuan Wang, Ying Huang, Liwei Wang, Zhixiu Chen, Lin Zhou, Xiang Feng, Guoyu Li, Jiawen Yang, Rui Chen, Qiang Xu, Yan Shen. TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development. Oncogene. 44(25):2054-2063(2025).
2.Yixuan Wang, Liwei Wang, Ying Huang, Lin Zhou, Guoyu Li, Jia-wen Yang, Xuefeng Wu, Jingcai Cheng, Qiang Xu, Yan Shen. Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73. Acta Pharmacol Sin. 46(6):1722-1732 (2025).
3. Jian Gao# , Zhixiu Chen# , Yixuan Wang# , Lele Guo , Minmin Fan , Lin Zhou , Liwei Wang , Ying Huang , Yang Sun , Wenjie Guo , Yan Shen , Qiang Xu. Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression. Fundamental Research. doi:https://doi.org/10.1016/j.fmre. (2024).
4. Yixuan Wang, Jian Gao, Ying Yu, Lin Zhou, Miao Wang, Wenwen Xue, Bo Liu, Xudong Wu, Xuefeng Wu, Huiyuan Gao, Yan Shen, Qiang Xu.A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.Br J Pharmacol. 180(2):194-213 (2023).
5. Ahmed Elgehama#, Yixuan Wang#, Ying Yu, Lin Zhou, Zhixiu Chen, Liwei Wang, Lijun Sun, Jian Gao, Biao Yu, Yan Shen, Qiang Xu. Targeting the PTP1B-Bcr-Abl1 interaction for the degradation of T315I mutant Bcr-Abl1 in chronic myeloid leukemia.Cancer Sci. 114(1):247-258 (2023).
6. Xue W, Li X, Li W, Wang Y, Jiang C, Zhou L, Gao J, Yu Y, Shen Y, Xu Q. Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer. Signal Transduct Target Ther. 4;7(1):35(2022).