刘寻
苏州大学附属第二医院副研究员
双创博士、姑苏卫生特聘人才
E-mail：lx8810@suda.edu.cn
个人简介:
刘寻是苏州大学附属第二医院副研究员、硕士生导师。围绕生物医用高分子材料设计和生物大分子药物胞内递送开展研究，他以第一作者、通讯作者在Angew Chem Int Ed、Adv Mater、Acc Mater Res等期刊发表论文近20篇。主持国家自然科学基金面上项目、国家自然科学基金青年项目（C类）、江苏省自然科学青年基金项目等项目，并入选江苏省双创博士、Journal of Materials Chemistry B新锐科学家。
研究方向:
1. 胞内蛋白药物递送研究
2. 肿瘤免疫治疗
3. 纳米药物用于眼部疾病研究
近五年代表性论文（*代表通讯作者）:
1. Ziyin Zhao#, Haoyu Zhang#, Wei Li#, Yehan Wang, Yifei Wang, He Yang, Lichen Yin*, Xun Liu*. Guanidyl-rich ɑ-helical polypeptide enables efficient cytosolic pro-protein delivery and CRISPR-Cas9 genome editing. J Mater Chem B, 2025, 13, 1991-2002.
2. Xun Liu#, Ziyin Zhao#, Wei Li#, Mengyao Ren, Haoyu Zhang, Desheng Cao, Yehan Wang, He Yang, Yajie Li, Manhui Zhu, Laiqing Xie*, Lichen Yin*. Rationally engineering pro-proteins and membrane-penetrating α‑helical polypeptides for genome editing toward choroidal neovascularization treatment. Adv Mater, 2024, 37(6), 2412366.
3. Jia Lv#, Xun Liu#, Lichen Yin*, Yiyun Cheng*. Rational Engineering of Cytosolic Delivery Systems for Protein Therapeutics. Acc Mater Res, 2024, 5, 1194-1209.
4. Qiang Yang#, Ningyu Liu#, Ziyin Zhao, Xun Liu*, Lichen Yin*. Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery. Nano Res, 2024, 17, 1760-1771.
5. Xun Liu#, Ziyin Zhao#, Wei Li, Ningyu Liu, Qiang Yang, Lichen Yin*. Engineering nucleotidoproteins for base pairing-assisted cytosolic delivery and genome editing. Angew Chem Int Ed, 2023, 62, e202307664. (VIP paper)
6. Xun Liu, Wenting Si, Ningyu Liu, Ziyin Zhao, Qiang Yang, Renxiang Zhou, Rongying Zhu, Shanzhou Duan, Yongbing Chen, Lichen Yin*. Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci Chin Chem, 2023, 66, 2634-2644.
7. Zhisong Sun#, Mengyao Ren#, Bingchen Shan*, Qiang Yang, Ziyin Zhao, Xun Liu*, Lichen Yin*. One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery. Biomater Sci, 2023, 11, 5653-5662.
8. Xun Liu#, Mengru Wang#, Jing Yan, Fan Wu, Ziyin Zhao, Qiang Yang, Renxiang Zhou, Yiran Zheng, Rongying Zhu*, Yongbing Chen*, Lichen Yin*. In situ formed, peritoneum-adhesive immunogels synergizing low-dose fractionated radiotherapy against colorectal peritoneal carcinomatosis. Adv NanoBiomed Res, 2023, 3, 2200175.
9. Xun Liu, Wei Li, Mengru Wang, Ningyu Liu, Qiang Yang, Yunjie He, Duanmin Hu, Rongying Zhu*, Lichen Yin*. Inflammatory Cell-Inspired Cascade Nanozyme Induces Intracellular Radical Storm for Enhanced Anticancer Therapy. Small Methods, 2023, 7, 2201641.
10. Jing Yan#, Xun Liu#, Chenglong Ge, Fan Wu, Huan Ye, Xingye Chen, Yuansong Wei, Renxiang Zhou, Shanzhou Duan, Rongying Zhu, Yiran Zheng, Lichen Yin*. Platelet pharmacytes for the hierarchical amplification of antitumor immunity in response to self-generated immune signals. Adv Mater, 2022, 34, 2109517.
11. Ziyin Zhao#, Xun Liu#, Mengying Hou, Renxiang Zhou, Fan Wu, Jing Yan, Wei Li, Yujia Zheng, Qinmeng Zhong, Lichen Yin*. Endocytosis-independent and Cancer-selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate. Adv Mater, 2022, 34, 2110560.
12. Xun Liu#, Ziyin Zhao#, Fan Wu, Yongbing Chen, Lichen Yin*. Tailoring Hyperbranched Poly(β-amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery. Adv Mater, 2022, 34, 2108116.
13. Rujian Lu#, Yujia Zheng#, Mengru Wang, Juanhui Lin, Ziyin Zhao, Lei Chen, Jiaheng Zhang, Xun Liu*, Lichen Yin*, Yongbing Chen*. Reactive oxygen species (ROS)-responsive branched poly(β-amino ester) with robust efficiency for cytosolic protein delivery. Acta Biomater, 2022, 152, 355-366.