黄波 特聘教授
苏州市生物学会青年委员会委员
E-mail：bohuang@suda.edu.cn
个人简介：
黄波，2018年于浙江大学获药物化学医学博士学位，随后分别在美国南佛罗里达大学及香港大学开展博士后研究工作。2025年加入苏州大学药学院。主要从事药物化学生物学研究，长期聚焦 “构象受限拟肽折叠体的理性设计及靶向功能转化” 这一前沿交叉领域。近年来，针对传统 “难成药” 靶点与天然多肽成药性差等科学难题，在转录复合体调控、非传统泛素化调控及外源性毒素捕获清除等方向取得多项原创性成果。以第一作者或通讯作者身份在 Nature Communications、Acta Pharmaceutica Sinica B、Journal of Medicinal Chemistry 等国际权威学术期刊发表多篇高质量论文，并获批 PCT 国际发明专利1项。目前担任苏州市生物学会青年委员会委员及 Acta Pharmaceutica Sinica B 等期刊审稿人。曾获博士生国家奖学金、浙江省及浙江大学优秀博士论文提名等荣誉。
研究方向：
1. 构象受限拟肽折叠体的理性设计及靶向功能转化
2. 仿生拟肽受体开发与体内外源性毒素捕获清除
3. 微环境驱动型拟肽离子载体的设计及其选择性抗肿瘤机制研究
4. 微环境响应型多肽构建及其长效减毒干预策略研究
代表性论文（*代表通讯作者）
[1]B. Huang, S. Li, C. Pan, F. Li, L. Wojtas, Q. Qiao, T. H. Tran, L. Calcul, W. Liu, C. Ke, J. Cai, "Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances" Nat. Commun. 2025, 16, 3226.
[2]B. Huang, E. Gregory-Lott, B. X. Li, T. H. Tran, S. Li, M. Xue, S. Wang, A. Asokan, N. Shen, X. Sun, C. Cao, X. Xiao, G. Daughdrill, J. Cai, "Discovery of peptidomimetic inhibitors of CREB/CBP by targeting hydrophobic grooves on the surface of the CBP KIX domain" Acta Pharm. Sin. B. 2025, 15, 6529–6545.
[3]B. Huang, M. Wang, E. Gregory-Lott, B. X. Li, Y. Y. Win, N. Shen, J. Chen, S. Li, C. Cao, X. Xiao, G. W. Daughdrill, J. Cai, "Recognition of the CREB-Binding Protein/Mixed Lineage Leukemia Interface by Sulfonyl-γ-AApeptides: Beyond Mimicry of Mixed Lineage Leukemia" J. Med. Chem. 2025, 68, 12272–12283.
[4]L. Zhou, I. H. Jeong, S. Xue, M. Xue, L. Wang, S. Li, R. Liu, G. H. Jeong, X. Wang, J. Cai, J. Yin, B. Huang, "Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix" J. Med. Chem. 2023, 66, 491–502.
[5]B. Huang, L. Zhou, R. Liu, L. Wang, S. Xue, Y. Shi, G. H. Jeong, I. H. Jeong, S. Li, J. Yin, J. Cai, "Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide" J. Med. Chem. 2022, 65, 2497–2506.
[6]P. Jadhav, B. Huang, J. Osipiuk, X. Zhang, H. Tan, C. Tesar, M. Endres, R. Jedrzejczak, B. Tan, X. Deng, A. Joachimiak, J. Cai, J. Wang, "Structure-based design of SARS-CoV-2 papain-like protease inhibitors" Eur. J. Med. Chem. 2024, 264, 116011.
[7]B. Huang, L. Zeng, Y. Shen, S. Cui, "One-Pot Multicomponent Synthesis of β-Amino Amides" Angew. Chem. Int. Ed. 2017, 56, 4565–4568.
[8]B. Huang, Y. Shen, Z. Mao, Y. Liu, S. Cui, "Metathesis Reaction of Diazo Compounds and para-Quinone Methides for C–C Double Bond Formation: Synthesis of Tetrasubstituted Alkenes and Quinolinones" Org. Lett. 2016, 18, 4888–4891.
[9]B. Huang, L. Zeng, Y. Shen, S. Cui, "Nickel-catalyzed acetamidation and lactamization of arylboronic acids" Chem. Commun. 2017, 53, 11996–11999.