地址: 111 St. Stephens Green, Dublin 2, Ireland
个人简介：
Helena教授是一名注册药剂师，毕业于都柏林圣三一大学(TCD)药剂学专业，研究重点是刺激反应性水凝胶和持续药物输送领域。完成博士学位后，Helena在制药和生物制药行业工作了八年，从事工艺开发和规模扩大、技术制造、临床试验制造和监管审批流程等业务。2008年她回到RCSI药学院。2022年她被任命为PBS的副主任(项目创新)，负责实施精密医学技术和分析理学硕士学位(TAPM)和先进治疗技术理学学士学位(ATT)项目。这些项目的开发得到了HEA人力资本倡议(HEA Human Capital Initiative) 780万欧元奖金的资助。Helena是组织工程研究小组(TERG)的首席研究员，也是AMCARE(心脏再生先进材料，FP7, 2013-2017)和DRIVE(糖尿病逆转植入物提高生存能力和长期疗效，地平线2020，2014-2018)两个欧盟联盟的首席研究员和副协调员。她领导了微创交付临床应用的水凝胶交付平台的制定。她发明了ChemoGel（一种用于肿瘤内药物输送的热响应水凝胶平台），其开发已通过爱尔兰企业商业化基金获得资助。2019年她参加了NSF-SFI创业科学家创新队(iCorps)计划。
研究方向：
她的研究重点在水凝胶技术，特别是水凝胶作为运载工具或生物材料载体的潜在临床应用。她关注水凝胶平台在一系列临床适应症中的应用潜力，包括心脏应用的组织再生，作为增强细胞活力的ECM，以及肿瘤应用的肿瘤内输送。
近期论文：
1. Simple technique for microscopic evaluation of active cellular invasion into 3D hydrogel constructs. [Journal Article] Simpson C, Cavanagh B, Kelly H, Murphy C Published 7 Feb 2023
2. A predictive oxygen durability model to analyze oxygen consumption of insulin producing cells encapsulated within a highly oxygenated hydrogel. [Journal Article] Domingo-Lopez DA, Levey RE, Brennan B, Carroll O, Gale SE, Millman JR, Mcdonough L, Kelly H, Ronan W, Duffy G Published 30 Sep 2022
3. The impact of epithelial–mesenchymal transition and metformin on pancreatic cancer chemoresistance: a pathway towards individualized therapy. [Journal Article] Kielaite-Gulla A, Andriusaityte U, Zdanys GT, Babonaite E, Strupas K, Kelly H Published 23 Mar 2022
4. Assessing the effects of VEGF releasing microspheres on the angiogenic and foreign body response to a 3D printed silicone-based macroencapsulation device. [Journal Article] Levey RE, Coulter FB, Scheiner KC, Deotti S, Robinson ST, McDonough L, Nguyen TT, Steendam R, Canney M, Wylie R, Burke LP, Dolan EB, Dockery P, Kelly H, Ghersi G, Hennink WE, Kok RJ, O'Cearbhaill E, Duffy GP Published 4 Dec 2021
5. A thermoresponsive chitosan/β-glycerophosphate hydrogel for minimally invasive treatment of critical limb ischaemia. [Journal Article] Herron C, Hastings CL, Herron-Rice C, Kelly H, O'Dwyer J, Duffy G Published 16 Oct 2021
6. Loco-regional drug delivery in oncology: current clinical applications and future translational opportunities. [Journal Article] Rossi SM, Murray T, Mcdonough L, Kelly H Published 16 Dec 2020
7. Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair. [Journal Article] Simpson C, Kelly H, Murphy C Published 27 Oct 2020
8. Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models. [Journal Article] Duffy GP, Robinson ST, O'Connor R, Wylie R, Mauerhofer C, Bellavia G, Straino S, Cianfarani F, Mendez K, Beatty R, Levey R, O'Sullivan J, McDonough L, Kelly H, Roche ET, Dolan EB Published 1 Jun 2020
9. Evaluation of the activity of a chemo-ablative, thermoresponsive hydrogel in a murine xenograft model of lung cancer. [Journal Article] Rossi SM, Ryan B, Kelly H Published 27 May 2020
10. Supporting the use of sildenafil infusions in paediatric and neonatal intensive care – A compatibility study. [Journal Article] Alsalman F, Howlett M, Breatnach C, Kelly H, O'Brien F Published 11 Apr 2020
11. A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction. [Journal Article] Dolan EB, Hofmann B, de Vaal MH, Bellavia G, Straino S, Kovarova L, Pravda M, Velebny V, Daro D, Braun N, Monahan DS, Levey RE, O'Neill H, Hinderer S, Greensmith R, Monaghan MG, Schenke-Layland K, Dockery P, Murphy BP, Kelly H, Wildhirt S, Duffy GP Published 1 Oct 2019
12. Tissue engineering: understanding the role of biomaterials and biophysical forces on cell functionality through computational and structural biotechnology analytical methods. [Journal Article] Almouemen N, Kelly H, O'Leary C Published 17 Apr 2019
13. Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles–development, characterisation, and in vitro assessment of bioactivity for cardiac applications. [Journal Article] Hameed A, Gallagher LB, Dolan E, O’Sullivan J, Ruiz-Hernandez E, Duffy GP, Kelly H Journal of Microencapsulation 36(3):267-277 Published 3 Apr 2019
14. A Custom Radiopaque Thermoresponsive Chemotherapy-Loaded Hydrogel for Intratumoural Injection: An In Vitro and Ex Vivo Assessment of Imaging Characteristics and Material Properties. [Journal Article] Rossi SM, Murray TE, Cassidy J, Lee M, Kelly HM Published 15 Feb 2019
15. Evaluation of the Immunomodulatory Effects of All-Trans Retinoic Acid Solid Lipid Nanoparticles and Human Mesenchymal Stem Cells in an A549 Epithelial Cell Line Model. [Journal Article] Payne C, Burke LP, Cavanagh B, O'Toole D, Cryan S-A, Kelly H Published 13 Feb 2019