詹启敏院士
国际分子肿瘤学家
中国工程院院士
个人简介：
詹启敏院士长期致力于肿瘤分子生物学和肿瘤转化医学研究，近年来，在基因组水平全面系统地揭示了食管癌的遗传突变背景，为了解食管癌的发病机理、寻找食管鳞癌诊断的分子标志物、确定研发临床治疗的药物靶点提供了理论和实验基础。他发表了SCI论文270多篇，包括Nature, Cell, Cell Research，Nature Communication，JCI, PNAS, Science, EMBO, Cancer Res, Oncogene等。发表的科技论文被SCI引用16200多次。主编主译学术著作7部，申报发明专利14项，获得授权专利8项。应邀在国内外学术会议上作大会报告120余次，15次担任国际会议或双边会议主席。应邀先后担任国际生物医学和肿瘤学杂志“Cancer Cell”“JBC”、“Molecular Oncology”和“Carcinogenesis”编委，担任“Data Health”和“Medical Review”主编，《科学通报》、《中华肿瘤杂志》副主编。应邀为国际肿瘤学重要杂志 “British J Cancer”和“Mutation Res”撰写综述。
研究方向：
肿瘤分子学；肿瘤转化医学研究
代表性论文：
1. Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014, 509(7498):91-95.
2. Shujuan Shao, Rong Liu, Yang Wang, Yongmei Song, Lihui Zuo, Liyan Xue, Ning Lu, Ning Hou, Mingrong Wang, Xiao Yang, Qimin Zhan.Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice, Journal of Clinical Investigation. 2010, 36(120): 498-507.
3. Li, X., L. Shi,Y.Wang, J. Zhong, X. Zhao, H.Teng, X. Shi, H. Yang, S. Ruan, M.Li, Z. S. Sun*, Q.Zhan* and F.Mao*. OncoBase: a platform for decoding regulatory somatic mutations in human cancers,2019, Nucleic Acids Research.2019, 47(D 1): D1044-D1055.
4. Yan T, Cui H, Zhou Y, Yang B, Kong P, Zhang Y, Liu Y, Wang B, Cheng Y, Li J, Guo S, Xu E, Liu H, Cheng C, Zhang L, Chen L, Zhuang X, Qian Y, Yang J, Ma Y, Li H, Wang F, Liu J, Liu X, Su D, Wang Y, Sun R, Guo S, Li Y, Cheng X, Liu Z, Zhan Q*, Cui Y*. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019, 10(1): 1670.
5. Dongdong Zhang, Weimin Zhang, Dan Li, Ming Fu, Runsheng Chen, Qimin Zhan. GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3. Autophagy.2015, 11(12): 2247-2258.
6. Dan Li, Xuefeng Liu, Jian Zhou, Jie Hu, Dongdong Zhang, Jing Liu, Yanyan Qiao, Qimin Zhan. Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as ascaffoldofextracellularsignal-regulated kinase and YB-1 to enhance hepatocarcinogenesis. Hepatology. 2017, 65(5):1612-1627.
7. Xuefeng Liu, Dan Li, Weimin Zhang, Mingzhou Guo, Qimin Zhan. Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay. EMBO Journal. 2012, 31(23): 4415–4427.
8. Cui Y, Chen H, Xi R, Cui H, Zhao Y, Xu E, Yan T, Lu X, Huang F, Kong P, Li Y, Zhu X, Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S, Zhang L, Liu Y, Wang B, Xi Y, Sun R, Yu X, Zhai Y, Wang F, Yang J, Yang B, Cheng C, Liu J, Song B, Li H, Wang Y, Zhang Y, Cheng X, Zhan Q*, Li Y*, Liu Z*. Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma. Cell Research.2020, 30(10): 902-913
9. Jie Chen, Yan Wang, Weimin Zhang, Di Zhao, Lingyuan Zhang, Jiawen Fan, Jinting Li, Qimin Zhan. Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells. Signal Transduction and Targeted Therapy. 2020, 5(139): 1-12.
10. Gao, X., Y. Wang, F. Lu, X. Chen, D. Yang, Y. Cao, W. Zhang, J. Chen, L. Zheng, G. Wang, M. Fu, L. Ma, Y. Song and Q. Zhan. Extracellular vesicles derived fromoesophagealcancercontainingP4HB promote muscle wasting viaregulatingPHGDH/Bcl-2/caspase-3 pathway, Journal of Extracellular Vesicles. 2021, 10(5): e12060.