姓名：滕昕辰
职称：副教授
职务：国际创新药学院副院长
邮箱: xcteng@suda.edu.cn
地址：国际创新中心902室
个人简介
复旦大学化学专业学士及硕士，美国约翰×霍普金斯大学医学院生物化学、细胞与分子生物学博士，约翰×霍普金斯大学公共卫生学院微生物与分子免疫系博士后。苏州大学药学院副教授和硕士生导师。入选江苏省“双创博士”、苏州市“紧缺人才”计划。主持2项国家自然科学基金项目和1项江苏省自然科学基金项目。
研究方向
肿瘤相关细胞生长信号通路机制研究
GSDM蛋白诱导炎性死亡—焦亡的调控机制
新型抗肿瘤和抗感染药物开发
宇宙辐射诱导的基因组进化
代表性论文
1. Wang Y, Ping Y, Zhou R, Wang G, Zhang Y, Yang X, Zhao M, Liu D, Kulkarni M, Lamb H, Niu Q, Hardwick JM*, Teng X*. (2025) The Whi2-Psr1-Psr2 complex selectively regulates TORC1 and autophagy under low leucine conditions but not nitrogen depletion. Autophagy. 21(8):1700-1716.
2. Wang Y, Engel T, Teng X* (2024) Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression, Biochim Biophys Acta Gene Regul Mech. 18672025:195005
3. Stolp ZD, Kulkarni M, Liu Y, Zhu C, Jalisi A, Lin S, Casadevall A, Cunningham KW, Pineda FJ, Teng X, Hardwick JM* (2022) Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization, Cell Rep. 39:110647
4. Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM* (2019) KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders, CNS Neurosci Ther. 25, 887-902.
5. Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X* (2019) Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, J Biol Chem. 294, 12921-12932.
6. Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM* (2018) KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect, Ann Neurol. 84, 766-780
7. Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM*, Teng X* (2018) Whi2 is a conserved negative regulator of TORC1 in response to low amino acids, PLoS Genetics. 14, e1007592
8. Teng X* and Hardwick JM* (2018) Whi2: a new player in amino acid sensing, Curr Genet. 65, 701-709.
9. Teng X, Yau E, Sing C, Hardwick JM (2018) Whi2 signals low amino acid availability to halt yeast growth and cell death, FEMS Yeast Res. 18, foy095
10. Teng X* and Hardwick JM* (2015) Cell death in genome evolution, Semin Cell Dev Biol. 39, 3-11
11. Teng X* and Hardwick JM* (2014) Genome evolution in yeast reveals connections between rare mutations in human cancers, Microb Cell. 1, 206-209
12. Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM (2013) Genome-wide consequences of deleting any single gene, Mol Cell. 52, 485-494.
13. Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM (2011) Gene-dependent cell death in yeast, Cell Death Dis.2, e188