姓 名：李博文
职称职务：特聘教授，博士生导师
电子邮件：bwli@suda.edu.cn
办公地址：苏州大学国际创新药学院801-2室
个人简介：
李博文，博士，苏州大学国际创新药学院、苏州创新药研究院双聘特聘教授，博士生导师。本科毕业于青岛科技大学，博士毕业于中国科学院上海有机化学研究所，师从汤文军研究员（国家杰青）。2021年至2025年在美国莱斯大学化学系从事博士后研究，合作导师为James M. Tour教授（美国国家工程院院士）。2026年6月加入苏州大学国际创新药学院、苏州创新药研究院。
已发表SCI论文28篇，其中以第一作者（含共同第一作者）或通讯作者发表论文10篇，包括J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、ACS Nano、Adv. Sci.等，担任Sci. Adv.、ACS Nano、Appl. Energy等国际学术期刊独立审稿人。
研究方向：
1. 新型光驱动分子机器的设计与创制
2. 分子机械作用驱动的纳米医学研究
3. 智能生物材料与药物递送系统开发
4. 创新药物分子的绿色高效合成
代表性论文（#代表共同第一作者，*代表通讯作者）：
1) Li, B.; Luo, B.; Yang, H.;* Tang, W.* Heck Reaction of N-Heteroaryl Halides for Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles. Angew. Chem. Int. Ed. 2022, 61, e202209087.
2) Li, B.; Li, T.; Aliyu. A. M.; Li, Z. H.; Tang, W.* Enantioselective Palladium-Catalyzed Cross-Coupling between α-Bromo Carboxamides and Arylboronic Acids. Angew. Chem. Int. Ed. 2019, 58, 11355–11359.
3) Li, B.#,*; Arnold, D.;# Rui, Y.;# Santos, A. L.; Beckham, J.; Xu, S.; Cheng, Y.; Si, T.; Liu, Q.; Tour, J. M.* Precise and Mechanical Control of Calcium Signaling in Muscle Cells by Near-Infrared-Activated Molecular Jackhammers. ACS Nano 2026, 20, 442–458.
4) Li, B.; Ayala-Orozco, C.;* Si, T.; Zhou, L.; Wang, Z.; Martí, A. A.; Tour, J. M.* Divergent Syntheses of Near-Infrared Light-Activated Molecular Jackhammers for Cancer Cell Eradication. Adv. Sci. 2024, 11, 2405965.
5) Li, B.; Luo, B.; Blakemore, C. A.;* Smith, A. C.; Widlicka, D. W.; Berritt, S.; Tang, W.* Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals. Org. Lett. 2021, 23, 6439–6443.
6) Li, B.; Aliyu, A. M.; Gao, Z.; Li, T.; Dong, W.; Shi, E.*; Tang, W.* General Synthesis of Chiral α, α-Diaryl Carboxamides by Enantioselective Palladium-Catalyzed Cross-Coupling. Org. Lett. 2020, 22, 4974–4978.
7) Arnold, D.;# Li, B.;# Beckham, J.; Lopez-Jaime, K.; Ayala-Orozco, C.; Rui, Y.; Chaudhry, G.; Seminario, J.; Tour, J. M.* Rotation Kinetics of Molecular Motors Influence their Ability to Kill Cancer Cells and Induce Cellular Calcium Signaling. J. Am. Chem. Soc. 2025, 147, 22387–22401.
8) Ayala-Orozco, C.;*,# Li, G.;# Li, B.;# Vardanyan, V.; Kolomeisky, A. B.;* Tour, J. M.* How to Build Plasmon-Driven Molecular Jackhammers that Disassemble Cell Membranes and Cytoskeletons in Cancer. Adv. Mater. 2024, 36, 2309910.
9) Rui, Y.;# Li, B.;#,* Vardanyan, V.; Kim, S.; Arnold, D.; Beckham, J.; Ayala-Orozco, C.; Santos, A. L.; Chaudhry, G.; Zhou, L.; Xu, S.; Si, T.; Wang, Z.; Marti, A.; Kolomeisky, A.; Robinson, J.; Tour, J. M.* Molecular Jackhammers Induce Intracellular Calcium Release and Skeletal Muscle Contraction by Vibronic-Driven Action. Chem. Sci. 2026, 17, 9938–9951.
10) Ayala-Orozco, C.;*,# Li, B.; # Li, G.; Tour, J. M.* Plasmon Hybridization Model in Molecules: Molecular Jackhammers. Chem. Sci. 2025, 16, 2718–2729.
11) Beckham, J. L.; van Venrooy, A. R.; Kim, S.; Li, G.; Li, B.; Duret, G.; Arnold, D.; Zhao, X.; Li, J. T.; Santos, A. L.; Chaudhry, G.; Liu, D.; Robinson, J. T.;* Tour, J. M.* Molecular machines stimulate intercellular calcium waves and cause muscle contraction. Nat. Nanotechnol. 2023, 18, 1051–1059.