姓 名：吴丹
职称职务：博士，特聘教授，博士生导师
江苏省特聘教授获得者
爱尔兰皇家外科医学院化学系PI
电子邮箱：danwu@suda.edu.cn; danwu@rcsi.com
联系电话：0512-65886007
办公地址：国际创新药学院801-1室
个人简介：
吴丹博士，特聘教授，博士生导师，2010年毕业于东华大学。同年，前往都柏林大学（UCD）攻读博士学位，并于2014年获得化学和生物化学专业博士学位。2015年至2018年间，他在爱尔兰皇家外科医学院（RCSI）化学系担任博士后研究员。2019年，作为访问学者在英国爱丁堡大学和赫瑞瓦特大学超分辨成像中心（ESRIC）进行学习。随后，他回到RCSI化学系担任讲师及独立PI至今。2024年5月，吴丹博士加入苏州大学国际创新药学院，被聘为特聘教授、博士生导师，担任国际创新药学院分子影像与智能医学实验室负责人。
吴丹博士及其研究团队致力于新型荧光影像及精准医学领域的研究，具体包括：开发新型近红外肿瘤靶向荧光标记药物（NIR-AZA）、近红外光激活抗癌和抗微生物药物、可生物正交的智能近红外荧光探针及其在生物超分辨荧光成像中的应用、荧光寿命成像（FLIM）、人工智能辅助化学以及基于荧光引导手术等。
作为独立课题组负责人（PI），吴丹博士曾主持并获得爱尔兰科学基金会55万欧元（约430万人民币）、爱尔兰研究委员会12.4万欧元（约97万人民币）以及全爱健康研究委员会45万欧元（约350万人民币）的研究资助，用于开展以人工智能辅助化学为重点的研究，特别关注新型化学反应产物预测、化学物质性质的分析以及未来应用在人工智能辅助新药研发方面。吴博士已在PNAS、Chem Sci、Theranostics、Chem Comm、Org Lett、Chem、Nature（Research highlight）、J. Med. Chem、Sci. Rep.和Pharmaceuticals等一流的药物化学期刊上发表了同行评审的研究论文40余篇。
研究方向：
1.开发基于BF2-azadipyrromethene 系列的近红外荧光探针及光动力治疗药物
2.近红外荧光引导手术– 靶向精准手术
3.四嗪生物正交化学：新型智能生物荧光探针
4.超高分辨荧光显微镜-STED, STORM, SRRF成像以及FLIM技术
5.人工智能化学反应预测及对复杂产物分析-应用于电子烟在使用者人群健康的评估
部分论文：
27.Kishimoto, A., Wu, D.*, O’Shea, D., Forecasting vaping health risks through neural network model prediction of flavour pyrolysis reactions, Sci. Rep. 2024,14, 9591.
26.Wu, D., Durán-Sampedro, G., Fitzgerald, S., Garre, M., O’Shea, D., Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B-Free Bioorthogonal Imaging, Chem Comm. 2023, 59, 1951-1954.
25.Caulfield, C., Wu, D., O’Shea, D, et al. BF2-Azadipyrromethene Fluorophores for Intraoperative Vital Structure Identification. Molecules, 2023, 28(5), 2167.
24.Caulfield, C., O’Shea, D., Wu, D.* Dynamic Bioorthogonal Imaging using a Tetrazine NIR-AZA Fluorogenic Probe, Tetrahedron, 2023, 138, 133387.
23.Curtin, N., Garre, M., Wu, D., O’Shea D. Identifying STEDable BF2-Azadipyrromethene Fluorophores, Molecules, 2023, 28(3), 1415.
22.Caulfield, C., Wu, D., Garre M., O’Shea, D., Substituent Directed Cellular Imaging in the 800-850 nm range with BF2-Azadipyrromethene Fluorophores, RSC Advances 2023,13, 14963-14973.
21.Wu, D., Aonghusa, PM., O’Shea, DF., Correlation of national and healthcare workers COVID-19 infection data; implications for large-scale viral testing programs, Plos One 2021, 16 (4), e0250699.
20.Curtin, N., Wu, D.,R Cahill, A Sarkar, P Mac Aonghusa, S Zhuk, M Barberio, Dual color imaging from a single BF2-Azadipyrromethene fluorophore demonstrated in vivo for lymph node identification. International journal of medical sciences 2021, 18 (7), 1541.
19.Wu, D.*, O' Shea, D.F. Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate. Proceedings of the National Academy of Sciences of the USA, 2020, 117 (12) 6349.
18.Daly, H.C., Conroy, E., Wu, D., Gallagher, W.M., O' Shea, D.F. An EPR strategy for bio-responsive fluorescence guided surgery with simulation of the benefit for imaging. Theranostics 2020; 10(7):3064.
17.Wu, D., O’Shea, D.F. Vaping additive yields an ‘exceptionally toxic’ by-product. Nature 579, 474 (2020) doi: https://doi.org/10.1038/d41586-020-00808-9 (research highlights)
16.Wu, D., Daly, H.C., Grossi, M., Conroy, E., Li, B., Gallagher, W.M., O'Shea, D.F. RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery. Chemical Science, 2019, 10, 6944.
15.Wu, D., Durán-Sampedro, G., O’Shea, D.F. Synthesis and properties of water soluble 1,9-dialkyl substituted BF2 azadipyrromethene (NIR-AZA) fluorophores. Frontiers of Chemical Science and Engineering, 2019,1-8.
14.Wu, D., Daly, H.C., Conroy, E., Li, B., Gallagher, W.M., Cahill, R.A., O'Shea, D.F. PEGylated BF2 azadipyrromethene (NIR-AZA) fluorophores for intraoperative imaging. European Journal of Medicinal Chemistry 2019, 161, 343.
13.Henari, F.Z., O’Shea, D., Wu, D., Nonlinear optical measurements of BF2 aza dipyrromethene fluorophores. Chemical Physics Letters: X, 2019, 100020.
12.Wu, D., Cheung, S., Sampedro, G., Chen, Z.-L., Cahill, R.A., O’Shea, D.F. A DIE responsive NIR-fluorescent cell membrane probe. BBA Biomembranes 2018, 1860, 2272.
11.Wu, D., D O' Shea, N Mulligan, E Loughman, HA Kockhar, R Cahill, Optical discrimination of primary colorectal cancer using systemic Indocyanine green with near-infrared laparoscopy and microscopy: clinical pilot experience, Irish Journal of medical science 2018,187, S159.
10.Monopoli, M.P., Zendrini, A., Wu, D., Cheung, S., Sampedro, G., Ffrench, B., Nolan, J., Piskareva, O., Stalings, R.L., Ducoli, S., Bergese, P., O’Shea, D.F. Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe. Chemical Communications 2018, 54, 7219.
9.Cheung, S., Wu, D., Daly, H., Busschaert, N.; Morgunova, M., Simpson, J., Scholz, D., Gale, P.A., O'Shea, D.F. Real-time recording of the cellular effects of the anion transporter prodigiosin. Chem 2018, 4, 879.
8.Kitteringham, E., Wu, D., Cheung, S., Twamley, B., O'Shea, D.F., Griffith, D.M. Development of a novel carboplatin like cytoplasmic trackable near infrared fluorophore conjugate via strain-promoted azide alkyne cycloaddition. Journal of Inorganic Biochemistry 2018, 182, 150.
7.Kaltner, H., Manning, J.C., Caballero, G.G., Di Salvo, C., Gabba, A., Romero-Hernandez, L.L., Knospe, C., Wu, D., Daly, H.C., O' Shea, D.F., Gabius, H.J., Murphy, P.V. Revealing bio-medically relevant cell and lectin type-dependent structure-activity profiles for glycoclusters by using tissue sections as an assay platform. RSC Advances 2018, 8, 28716.
6.Wu, D., O’Shea, D.F. Fluorogenic NIR-probes based on 1,2,4,5-tetrazine substituted BF2-azadipyrromethenes. Chemical Communications 2017, 53, 10804.
5.Wu, D., O’Shea, D.F. Comparative triad of routes to an alkyne-BF2 azadipyrromethene near-infrared fluorochrome. Tetrahedron Letters 2017, 58(47), 4468.
4.Wu, D., Cheung, S., O' Sullivan, C.J., Gao, Y.H., Chen, Z.L., O' Shea, D.F. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances 2016, 6, 87373.
3.Wu, D., Cheung, S., Devocelle, M., Zhang, L., Chen, Z.L., O’Shea, D.F. Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome. Chemical Communications 2015, 51, 16667.
2.Wu, D., Cheung, S., Daly, R., Burke, H., Scanlan, E.M., O’Shea, D.F. Synthesis and glycoconjugation of an azido BF2 azadipyrromethene near-infrared fluorochrome. European Journal of Organic Chemistry 2014, 6841.
1.Wu, D., O’Shea, D.F. Synthesis and Properties of BF2-3,3-Dimethyldiaryl azadipyrromethene near-infrared fluorophores. Organic Letters 2013, 15, 3392.