Dr. Qiuwen Wang
Distinguished Professor
E-mail：qwwang@suda.edu.cn
Address: Room 509-2, International College of Pharmaceutical Innovation, Soochow University
Biography
Dr. Qiuwen Wang. Professor, Principal Investigator, and Ph.D. Supervisor at International College of Pharmaceutical Innovation, Soochow University. Dr. Qiuwen Wang obtained her bachelor’s degree from Shandong Normal University and her Ph.D. from Tsinghua University, during which she was jointly trained at Harvard Medical School. Before returning to China in 2025, she worked as a postdoctoral fellow at the Salk Institute for Biological Studies in California, USA. She has published 13 SCI papers in leading journals, with more than 1,000 citations. As the first author or co–first author, she has published multiple research articles in top journals, including Nature Neuroscience (IF 25.7), Nature (IF 54.4), PNAS (IF 10.8), and Cell Reports (IF 7.5), etc. She has been granted five invention patents, including four international patents and one Chinese patent. Her main research interests focus on neurological disorders, brain organoids, and aging.
Research Interests：
1. Pathological mechanisms of aging-related neurodegenerative diseases
2. Development of novel organoids and cell-based therapies
3. Mechanistic studies of bipolar disorder pathogenesis
4. Discovery and development of new drugs for neurological diseases
Publications (* represents first author)
1. Yaonan Liu*, Qiuwen Wang*, Xinyu She*, Lijun Li*, Bing Wang, Ruilan Yang, Qian Li, Siyao Lu, Yinghan Wang, Wei Shen, Chonglei Fu, Lan Yi1, Chunxue Wang, Wei Shi, Xin Cheng, Liping Cao, Shuangli Mi, and Jun Yao. A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nature Neuroscience 2025. https://doi.org/10.1038/s41593-025-02040-y.
2. Yaonan Liu, Qiuwen Wang, Siyao Lu, Wei Shen, Chongye Guo, Zhikai Xing, Chang Li, Shan Sun, Senfang Sui, Shuangli Mi, Fred H Gage, Jun Yao. Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice. iScience 2025. https://doi.org/10.1016/j.isci.2025.112354.
3. Qiuwen Wang*, Junhong Qin*, Yanfen Chen*, Yingfeng Tu*, Yunyun Xing, Yuchen Wang, Lvyu Yang, Siyao Lu, Libo Geng, Wei Shi, Yiming Yang, Jun Yao. 16p11.2 CNV gene Doc2α contributes to neurodevelopment and social/repetitive behaviors through interacting with Secretagogin. Cell Reports 2023. doi: 10.1016/j.celrep.2023.112691.
4. Qiuwen Wang*, Yinghan Wang, Bing Wang, Yun Chen, Siyao Lu, Jun Yao. Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants. PLOS Biology 2021. doi:org/ 10.1371/journal.pbio.3001323.
5. Siyao Lu, Chonglei Fu, Liang L, Bo Yang, Wei Shen, Qiuwen Wang, Yun Chen, Yanfen Chen, Yaonan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, and Jun Yao. miR-218-2 regulates cognitive functions in the hippocampus through C3-dependent modulation of synaptic vesicle release. PNAS 2021. doi:10.1073/pnas.2021770118.
6. Yun Chen, Yinghan Wang, Yi Zheng, Meijing Li, Bing Wang, Qiuwen Wang, Chonglei Fu, Yaonan Liu, Xueming Li, Jun Yao. Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons. Cell Reports 2021. doi: 10.1016/j.celrep.2021.108842.
7. Qiuwen Wang*, Siyao Lu*, Yaonan Liu*, Yun Chen, Hui Wei, Wei Shen, Yanfen Chen, Chonglei Fu, Yinghan Wang, Anbang Dai, Xuan Huang, Fred H. Gage, Qi Xu, and Jun Yao. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. PNAS 2020. doi:10.1073/pnas.2016416117.
8. Wei Shen*, Qiuwen Wang*, Yao-nan Liu*, Maria C. Marchetto, Sara Linker, Si-yao Lu, Yun Chen, Chuihong Liu, Chong-ye Guo, Zhikai Xing, Wei Shi, John R. Kelsoe, Martin Alda, Hongwei Wang, Yi Zhong, Sen-Fang Sui, Mei Zhao, Yiming Yang, Shuangli Mi, Liping Cao, Fred H. Gage, and Jun Yao. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. PNAS 2020. doi: 10.1073/pnas.1918165117.
9. Xuan Huang, Shan Sun, Xiaojing Wang, Fenghui Fan, Qiang Zhou, Shan Lu, Yong Cao, Qiuwen Wang, Mengqiu Dong, Jun Yao, Sengfang Sui. Mechanistic insights into the SNARE complex disassembly. Science Advances 2019. doi: 10.1126/ sciadv.aau 8164.
10. S Stern, R Santos, M C Marchetto, A P D Mendes, G A Rouleau, S Biesmans, Qiuwen Wang, J Yao, P Charnay, A G Bang, M Alda and, Fred H Gage. Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. Molecular Psychiatry 2018. doi: 10.1038/mp.2016.260.
11. Mertens J*, Qiuwen Wang*, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, PBDS, Mi S, Brennand KJ, Kelsoe JR, Fred H Gage, Jun Yao. Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature 2015. doi:10.1038/nature15526.
