Dr. Xun Liu
Associate Researcher
Jiangsu Dual-Creation Doctor
Journal of Materials Chemistry B “2025 Emerging Investigator”
E-mail：lx8810@suda.edu.cn
Biography：
Xun Liu is an associate researcher at the Second Affiliated Hospital of Soochow University. His research focuses on the development of polymeric nanocarriers and pro-protein engineering strategies for cytosolic delivery of proteins/peptides. He has co-authored nearly 20 papers in journals including Angew Chem Int Ed, Adv Mater, and Acc Mater Res. He has led projects including the General Program and Youth Program (Type C) of the National Natural Science Foundation of China, and the Youth Program of the Natural Science Foundation of Jiangsu Province. He has been honored as a Jiangsu Dual-Creation Doctor and an “Emerging Investigator” (2025) of Journal of Materials Chemistry B.
Selected Publications：
1. Ziyin Zhao#, Haoyu Zhang#, Wei Li#, Yehan Wang, Yifei Wang, He Yang, Lichen Yin*, Xun Liu*. Guanidyl-rich ɑ-helical polypeptide enables efficient cytosolic pro-protein delivery and CRISPR-Cas9 genome editing. J Mater Chem B, 2025, 13, 1991-2002.
2. Xun Liu#, Ziyin Zhao#, Wei Li#, Mengyao Ren, Haoyu Zhang, Desheng Cao, Yehan Wang, He Yang, Yajie Li, Manhui Zhu, Laiqing Xie*, Lichen Yin*. Rationally engineering pro-proteins and membrane-penetrating α‑helical polypeptides for genome editing toward choroidal neovascularization treatment. Adv Mater, 2024, 37(6), 2412366.
3. Jia Lv#, Xun Liu#, Lichen Yin*, Yiyun Cheng*. Rational Engineering of Cytosolic Delivery Systems for Protein Therapeutics. Acc Mater Res, 2024, 5, 1194-1209.
4. Qiang Yang#, Ningyu Liu#, Ziyin Zhao, Xun Liu*, Lichen Yin*. Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery. Nano Res, 2024, 17, 1760-1771.
5. Xun Liu#, Ziyin Zhao#, Wei Li, Ningyu Liu, Qiang Yang, Lichen Yin*. Engineering nucleotidoproteins for base pairing-assisted cytosolic delivery and genome editing. Angew Chem Int Ed, 2023, 62, e202307664. (VIP paper)
6. Xun Liu, Wenting Si, Ningyu Liu, Ziyin Zhao, Qiang Yang, Renxiang Zhou, Rongying Zhu, Shanzhou Duan, Yongbing Chen, Lichen Yin*. Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci Chin Chem, 2023, 66, 2634-2644.
7. Zhisong Sun#, Mengyao Ren#, Bingchen Shan*, Qiang Yang, Ziyin Zhao, Xun Liu*, Lichen Yin*. One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery. Biomater Sci, 2023, 11, 5653-5662.
8. Xun Liu#, Mengru Wang#, Jing Yan, Fan Wu, Ziyin Zhao, Qiang Yang, Renxiang Zhou, Yiran Zheng, Rongying Zhu*, Yongbing Chen*, Lichen Yin*. In situ formed, peritoneum-adhesive immunogels synergizing low-dose fractionated radiotherapy against colorectal peritoneal carcinomatosis. Adv NanoBiomed Res, 2023, 3, 2200175.
9. Xun Liu, Wei Li, Mengru Wang, Ningyu Liu, Qiang Yang, Yunjie He, Duanmin Hu, Rongying Zhu*, Lichen Yin*. Inflammatory Cell-Inspired Cascade Nanozyme Induces Intracellular Radical Storm for Enhanced Anticancer Therapy. Small Methods, 2023, 7, 2201641.
10. Jing Yan#, Xun Liu#, Chenglong Ge, Fan Wu, Huan Ye, Xingye Chen, Yuansong Wei, Renxiang Zhou, Shanzhou Duan, Rongying Zhu, Yiran Zheng, Lichen Yin*. Platelet pharmacytes for the hierarchical amplification of antitumor immunity in response to self-generated immune signals. Adv Mater, 2022, 34, 2109517.
11. Ziyin Zhao#, Xun Liu#, Mengying Hou, Renxiang Zhou, Fan Wu, Jing Yan, Wei Li, Yujia Zheng, Qinmeng Zhong, Lichen Yin*. Endocytosis-independent and Cancer-selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate. Adv Mater, 2022, 34, 2110560.
12. Xun Liu#, Ziyin Zhao#, Fan Wu, Yongbing Chen, Lichen Yin*. Tailoring Hyperbranched Poly(β-amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery. Adv Mater, 2022, 34, 2108116.
13. Rujian Lu#, Yujia Zheng#, Mengru Wang, Juanhui Lin, Ziyin Zhao, Lei Chen, Jiaheng Zhang, Xun Liu*, Lichen Yin*, Yongbing Chen*. Reactive oxygen species (ROS)-responsive branched poly(β-amino ester) with robust efficiency for cytosolic protein delivery. Acta Biomater, 2022, 152, 355-366.
