Huabing Chen
Professor
Tel: 18094258118
Email: chenhb@suda.edu.cn
Add: Room 1331, Yuxuan Building, Dushu Lake Campus, Suzhou
Biography
After graduating from Huazhong University of Science and Technology in 2008, he started his postdoctoral research in Professor Gao Jinming's laboratory at the University of Texas Southwestern Medical Center and Professor Kataoka's laboratory at the University of Tokyo. After returning to China in 2012, he established the laboratory of Nanomedicine and Molecular Imaging, and the team has 3 professors, 4 associate professors and more than 20 graduate students. As a project leader, He undertook the National Natural Science Foundation for Outstanding Young People Science Fund (2021), Outstanding Young People Science Fund (2014), face Project, Youth Fund, as well as Jiangsu Province Double Innovation Plan (2014), Suzhou Universities, research institutes in short supply of high-level talent Introduction funding Program, Jiangsu Province 333 high-level talent Training project (2018) National and provincial projects. As a core member, he participated in the construction of the State Key Laboratory of Radiation Medicine and Radiation Protection, the project of Double Innovation Plan (team), the superior discipline of Special Medicine in Jiangsu Province, and the Key Laboratory of Diagnosis and Treatment Technology Research of Major Neuropsychiatric Diseases in Jiangsu Province. As an academic backbone, he has participated in the research of major projects such as the National Major Scientific Research Plan and the National Support Plan. While working abroad, he participated in the FIRST project of Japan's large-scale scientific research program and the nanomedicine research project of NIH in the United States. In terms of teaching, he has undertaken the undergraduate courses Pharmacy and Pharmaceutics in English, the professional frontier courses Nanotechnology and the Reform of Biomedicine etc.The online course Pharmacy was selected as the first-class course in Jiangsu Province. For postgraduate students, he teaches Advances in Pharmaceutical Research, Modern Pharmaceutics, Modern Pharmaceutics and Drug Discovery and other courses.
So far, he has published more than 60 SCI papers. As the corresponding author, he has published more than 30 papers in Adv. Mater., ACS Nano, Adv. Funct. Mater., Biomaterials, Theranostics, J. Control. Release and other journals. Among them, nearly 30 papers have an impact factor greater than 10, and more than 10 papers have high ESI citation. He participated in the compilation of the textbook Pharmacy, Nanomedics, Bioinspired and Biomimetic Systems for Drug and Gene Delivery, Advances in Nanotheranostics II: Cancer Theranostic Nanomedicine and other monographs.
Research Interests
1. Tumor targeting nanomedicine: To construct a multi-functional, targeted and intelligent nanodrug-carrying system, by enhancing drug delivery efficiency, regulating tumor microenvironment and immune microenvironment, exploring new synergistic mechanisms, etc., to achieve efficient collaborative treatment of tumors (such as the synergistic treatment of light therapy with chemotherapy, immunotherapy and radiotherapy, etc.), and provide a new strategy for the efficient treatment of highly lethal and refractory tumors such as pancreatic cancer.
2. High-performance nanoimage probe: Through the intelligent and functional design of polymer carrier, the nanoprobe can achieve ultra-sensitive, intelligent and high-contrast detection of tumors with high spatial resolution, providing a new means for early tumor detection and accurate surgical navigation.
3. New nanomedicine technology and clinical transformation: To construct the preparation technology of nanomedicine carriers with clinical application prospects (such as single-molecule albumin nanoparticles, micelles, liposomes, nanocrystals and nanoemulsions, etc.), develop new nanomedicine preparations with high efficiency and low toxicity, and realize the clinical transformation of innovative products.
Recent Publications
66. B. Liu#, J Jiao#, W Xu, M Zhang, P Cui, Z Guo, Y Deng*, H Chen*, and W Sun*. Highly Efficient far-red/NIR-absorbing neutral Ir(III) complex micelles for potent photodynamic/photothermal therapy. Adv Mater, 2021, 33, 2100795
65. Z Guo#, H He#, Y Zhang#, J Rao#, T Yang, T Li, L Wang, M Shi, M Wang, S Qiu, X Song, H Ke, and H Chen*. Heavy-atom-modulated supramolecular assembly increases antitumor potency against malignant breast tumors via tunable cooperativity, Adv Mater, 2021, 33, 2004225.
64. M He#, T Yang#, Y Wang, M Wang, X Chen, D Ding*, Y Zheng*, H Chen*, Immune checkpoint inhibitor-based strategies for synergistic cancer therapy, Adv Healthc Mater, 2021, 10, 2002104
63. Z Wang#, Y Wang#, Y Wang#, C Wei, Y Deng, H Chen, J Shen*, H Ke*. Biomineralized iron oxide–polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation, J. Mater. Chem. B, 2021, 9, 1781-1786.
62. H Iqbal, T Yang, T Li, M Zhang, H Ke, D Ding, Y Deng* H Chen*. Serum protein-based nanoparticles for cancer diagnosis and treatment., J Control Release, 2021, 329, 997-1022.
61. Y Zhang#, M Shi#, Z Yan#, S Zhang#, M Wang, H Xu, H Li, Y Ying, S Qiu, J Liu*, H Yang, H Chen, H He*, Z Guo*. Ultrastable near-infrared nonlinear organic chromophore nanoparticles with intramolecular charge transfer for dually photoinduced tumor ablation, Adv Healthc Mater, 2020, 9, 2001042.
60. Z Yan#, M Wang#, M Shi, Y He, Y Zhang, S Qiu, H Yang, H Chen, H He*, Z Guo*. Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy, J Mater Chem B, 2020, 8, 6886-6897.
59. C Li#, J Wang*, Y Wang#, H Gao#, G Wei#, Y Huang#, H Yu#, Y Gan#, Y Wang#, L Mei#, H Chen#, H Hu#, Z Zhang#, Y Jin#. Recent progress in drug delivery, Acta Pharmaceutica Sinica B, 2019, 9, 1145-1162.
58. Q Guo, Q Zhu, T Miao, J Tao, X Ju, Z Sun, H Li, G Xu, H Chen, L Han*. LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases, J Control Release, 2019, 303, 117-129.
57. W Ke#, J Li#, F Mohammed, Y Wang, K Tou, X Liu, P Wen, H Kinoh, Y Anraku, H Chen, K Kataoka, Z Ge*. Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy, ACS Nano, 2019, 13, 2357-2369.
56. H Zhao#, J Xu, W Huang, G Zhan, Y Zhao*, H Chen*, X Yang*. Spatiotemporally light-activatable platinum nanocomplexes for selective and cooperative cancer therapy, ACS Nano, 2019, 13, 6647-6661.
55. H Chen#, Z Gu#, H An, C Chen, J Chen, R Cui, S Chen, W Chen, X Chen, X Chen, Z Chen, B Ding, Q Dong, Q Fan, T Fu, D Hou, Q Jiang, H Ke, X Jiang, G Liu, S Li, T Li, Z Liu, G Nie, M Ovais, D Pang, N Qiu, Y Shen, H Tian, C Wang, H Wang, Z Wang, H Xu, J Xu, X Yang, S Zhu, X Zheng, X Zhang, Y Zhao, W Tan*, X Zhang*, Y Zhao*. Precise nanomedicine for intelligent therapy of cancer, Sci China Chem, 2018, 61, 1503-1552.
54. X Lv, X Wang, T Li, C Wei, Y Tang, T, Yang, Q Wang, X Yang, H Chen, J Shen*, H Yang*, H Ke*. Rationally designed monodisperse Gd2O3/Bi2S3 hybrid nanodots for efficient cancer theranostics, Small, 2018, 14, 1802904.
53. S Ye, J Rao, S Qiu, J Zhao, H He*, Z Yan, T Yang, Y Deng, H Ke, H Yang, Y Zhao, Z Guo*, H Chen*. Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy, Adv Mater, 2018, 30, 1801216.
52. Y Tang, T Yang, Q Wang, X Lv, X Song, H Ke, Z Guo, X Huang, J Hu, Z Li, P Yang*, X Yang*, H Chen*. Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics, Biomaterials, 2018, 154, 248-260.
51. Y Wang, Y Deng, H Luo, A Zhu, H Ke, H Yang, H Chen*. Light-responsive nanoparticles for highly efficient cytoplasmic delivery of anticancer agents, ACS Nano, 2017, 11, 12134-12144.
50. T Yang, H Ke, Q Wang, Y Tang, Y Deng*, H Yang, X Yang, P Yang, D Ling, C Chen, Y Zhao, H Wu*, H Chen*. Bifunctional tellurium nanodots for photo-induced synergistic cancer therapy, ACS Nano, 2017, 11, 10012-10024.
49. H Luo, Q Wang, Y Deng, T Yang, H Ke, H Yang, H He, Z Guo, D Yu, H Wu, H Chen*. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy, Adv Funct Mater, 2017, 27, 1702834.
48. J Li, K Wei, S Zuo, Y Xu, Z Zha, W Ke, H Chen*, Z Ge*. Light-triggered clustered vesicles with self-supplied oxygen and tissue penetrability for photodynamic therapy against hypoxic tumor, Adv Funct Mater, 2017, 27, 1702108.
47. R Wen, X Lv, T Yang, Y Li, Y Tang, X Bai, H Ke*, J Shen*, H Chen*. Albumin nanoreactor-templated synthesis of Gd2O3/CuS hybrid nanodots for cancer theranostics, Sci China Mater, 2017, 60, 554-562 (Invited paper).
46. T Yang, L Liu, Y Deng, Z Guo, G Zhang, Z Ge*, H Ke*, H Chen*. Ultrastable near-infrared conjugated polymer nanoparticles for dually photoactive tumor inhibition, Adv Mater, 2017, 29, 1700487.
45. M Zhang, L Xing, H Ke, Y He, P Cui, Y Zhu, G Jiang, J Qiao, N Lu, H Chen*, H Jiang*. MnO2-based nanoplatform serves as drug vehicle and MRI contrast agent for cancer theranostics, ACS Appl Mater Interfaces, 2017, 9, 11337-11344.
44. H He, S Ji, Y He, A Zhu, Y Zou, Y Deng, H Ke, H Yang, Y Zhao*, Z Guo*, H Chen*. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-induced cancer therapy, Adv Mater, 2017, 29, 1606690.
43. T Yang, Y Tang, L Liu, X Lv, Q Wang, H Ke, Y Deng, H Yang, X Yang, G Liu, Y Zhao, H Chen*. Size-dependent Ag2S nanodots for second near-infrared fluorescence/photoacoustics imaging and simultaneous photothermal therapy. ACS Nano, 2017, 11, 1848–1857.
42. L Zhou, T Yang, J Wang, Q Wang, X Lv, H Ke, Z Guo, J Shen, Y Wang*, C Xing*, H Chen*. Size-tunable Gd2O3@albumin nanoparticles conjugating Chlorin e6 for magnetic resonance imaging-guided photo-induced therapy. Theranostics, 2017, 7, 764-774.
41. Y Deng, L Huang, H Yang*, H Ke, H He, Z Guo, T Yang, A Zhu, H. Wu*, H Chen*. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy. Small, 2017, 13, 1602747.
40. J Li, X He, Y Zou, D Chen, L Yang, J Rao, H Chen, M Chan, L Li, Z Guo, L Zhang*, C Chen. Mitochondria-targeted platinum(II) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of beta-catenin. METALLOMICS, 2017, 9, 726-733.
39. S Song, H Shen*, T Yang, L Wang, H Fu, H Chen, Z Zhang*. Indocyanine green loaded Magnetic Carbon Nanoparticles for Near Infrared Fluorescence/Magnetic Resonance Dual-modal imaging and photothermal therapy of tumor. ACS Appl Mater Interfaces, 2017, 9, 9484-9495.
38. Z Guo, Y Zou, H He, J Rao, S Ji, X Cui, H Ke, Y Deng, H Yang, C Chen, Y Zhao, H Chen*. Bifunctional platinated nanoparticles for photo-induced tumor ablation. Adv Mater, 2016, 28, 10155-10164.
37. T Yang, Y Wang, H Ke, Q Wang, X Lv, H Wu, Y Tang, X Yang, C Chen, Y Zhao, H Chen*. Protein nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Adv Mater, 2016, 28, 5923-5930.
36. X An, A Zhu, H Luo, H Ke, H Chen*, Y Zhao*. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy. ACS Nano, 2016, 10, 5947-5958.
35. Y Ma, J Huang, S Song, H Chen*, Z Zhang*. Cancer-targeted nanotheranostics: recent advances and perspectives. Small, 2016, 12, 4936-4954.
34. X Ai, C Ho, J Aw, A Attia, J Mu, Y Wang, X Wang, Y Wang, X Liu, H Chen, M Gao, X Chen, E Yeow, G Liu, M Olivo, B Xing*. In vivo covalent cross-linking of photo-converted rare-earth nanostructures for tumor localization and theranostics. Nat Commun, 2016, 7, 10432.
33. Y Li, Y Deng, X Tian, H Ke*, M Guo, A Zhu, T Yang, Z Guo, Z Ge, X Yang, H Chen*. Multi-pronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor. ACS Nano, 2015, 9, 9626-9637.
32. A Zhu, K Miao, Y Deng, H Ke, H He, T Yang, M Guo, Y Li, Z Guo, Y Wang, X Yang, Y Zhao*, H Chen*. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano, 2015, 9,7874-7885.
31. Y Wang, T Yang, H Ke, A Zhu, Y Wang, J Wang, J Shen, G Liu, C Chen, Y Zhao, H Chen*. Smart albumin-biomineralized nanocomposites for multimodal imaging and photothermal tumor ablation. Adv Mater, 2015, 27, 3874-3882.
30. J Huang, M Guo, H Ke, C Zong, B Ren*, G Liu, H Shen, Y Ma, X Wang, H Zhang, Z Deng, H Chen*, Z Zhang*. Rational design and synthesis of γFe2O3@Au magnetic gold nanoflowers for efficient cancer theranostics. Adv Mater, 2015, 27, 5049-5056.
29. M Guo, J Huang, Y Deng, H Shen, Y Ma, M Zhang, A Zhu, Y Li, H He, Y Wang, X Yang, Z Zhang*, H Chen*. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy. Adv Funct Mater, 2015, 25, 59-67.
28. J Li, Z Lyv, Y Li, H Liu, J Wang, W Zhan, H Chen*, H Chen*, X Li*. A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug. Biomaterials, 2015, 51, 12-21.
27. H Chen, L Xiao, Y Anraku, P Mi, X Liu,H Cabral, A Inoue, T Nomoto, A Kishimura*, N Nishiyama*, K Kataoka*. Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J Am Chem Soc, 2014, 136, 157-163.
26. M Guo, H Mao, Y Li, A Zhu, H He, H Yang, Y Wang, X Tian, C Ge, Q Peng, X Wang, X Yang, X Chen, G Liu*, H Chen*. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials, 2014, 35, 4656-4666.
25. Z Wan, H Mao, M Guo, Y Li, A Zhu, H Yang, H He, J Shen, L Zhou, Z Jiang, C Ge, X Chen, X Yang, G Liu, H Chen*. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics, 2014, 4, 399-411.
24. H Liu#, Y Li#, Z Lyu#, Y Wan, X Li, H Chen, H Chen, X Li*. Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity. J Mater Chem B, 2014, 2, 8303-8309.
23. H Yang, H Mao, Z Wan, A Zhu, M Guo, Y Li, X Li, J Wan, X Yang, X Shuai, H Chen*. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34, 9124-9133.
22. G Huang#, H Chen#, Y Dong#, X Luo, H. Yu, ZMoore, E Bey, D Boothman*, J Gao*. Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics, 2013, 3,116-126.
21. H Zhu, J Hao, H Chen, S Jiang, M Liu, H Sun, H Xu, J Zhang, X Yang*. Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: In vitro and in vivo evaluation. J Pharm Sci-us, 2013, 102,2332-2340.
20. H Chen, H Zhu, J Hu, Y Zhao, Q Wang, J Wan, Y Yang, H Xu, X Yang*. Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine. ACS Nano, 2011, 5, 2671-2680.
19. H Chen, C Khemtong, X Yang, X Chang, J Gao*. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today, 2011, 16, 354-360.
18. D Mou, H Chen, J Wan, H Xu, X Yang*. Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility. Int J Pharm, 2011, 413, 237-224.
17. W Xiong, W Wang, Y Wang, Y Zhao*, H Chen, H Xu, X Yang. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy. Colloids Surf B, 2011, 84, 447-453.
16. L Xiao, X Xiong, X Sun, Y Zhu, H Yang, H Chen, L Gan*, H Xu, X Yang*. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials, 2011, 32, 447-453.
15. H Chen, L Xiao, D Du, D Mou, H Xu, X Yang*. A facile construction strategy of highly stable nanoparticles for drug delivery using a hydrogel-thickened microemulsion system as a template. Nanotechnology, 2010, 21, 5148-5157.
14. C Mao, J Wan, H Chen, H Xu, X Yang*. The composition of oil phase modulates venous irritation of lipid emulsion-loaded diallyl trisulfide. Drug Development and Industrial Pharmacy, 2010, 36, 698-704.
13. E Blanco, E A Bey, C Khemtong, S-G Yang, J Setti-Guthi, H Chen, C W Kessinger, K A Carnevale，W G Bornmann*, D A Boothman, J Gao*. β-Lapachone micellar nanotherapeutics for non–small cell lung cancer therapy. Cancer Res, 2010, 70, 3896-3904.
12. H Chen, H Zhu, J Zheng, D Mou, J Wan, J Zhang, T Shi, Y Zhao, H Xu, X Yang*. The iontophoresis-driven penetration of lecithin-based nanovesicles through microneedle-induced skin microchannels for transdermal delivery of insulin. J Control Release, 2009, 139, 63-72.
11. C Mao, J Wan, H Chen, H Xu, X Yang*. Emulsifiers’ composition modulates venous irritation of the nanoemulsions as a lipophilic and venous irritant drug delivery system. AAPS PharmSciTech, 2009, 10, 1058.
10. H Chen, J Wan, Y Wan, D Mou, H Liu, H Xu, X Yang*. A facile nanoaggregation strategy for oral delivery of hydrophobic drug by utilizing acid-base neutralization reaction. Nanotechnology, 2008, 19, 375104.
9. L Xu, H Chen, H Xu, X Yang*. Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles. Eur J Pharm Biopharm, 2008, 70, 741-748.
8. D Mou, H Chen*, D Du, C Mao, J Wan, H Xu, X Yang*. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm, 2008, 353, 270-276.
7. H Chen, D Mou, D Du, X Chang, D Zhu, J Liu, H Xu, X Yang*. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. Int J Pharm, 2007, 341, 78-84.
6. J Liu, W Hu, H Chen, Q Ni, H Xu, X Yang*. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm, 2007, 328, 191-195.
5. H Chen, X Chang, D Du, W Liu, J Liu, T Weng, Y Yang, H Xu, X Yang*. Podophyllotoxin-loaded Solid lipid nanoparticles for epidermal targeting. J Control Release, 2006, 110, 296-306.
4. H Chen, X Chang, D Du, J Li, H Xu, X Yang*. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm, 2006, 315, 52-58.
3. X Chang, H Chen, X Zhao, Z Gao, H Xu, X Yang*. High-performance liquid chromatography determination of triptolide in vitro permeation studies. Analytica Chimica Acta, 2005, 534, 215-221.
2. H Chen, X Chang, T Weng, X Zhao, Z Gao,Y Yang, H Xu, X Yang*. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release, 2004, 98, 427-436.
1. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm, 2003, 56, 189-196.
