Dan Wu
PhD, Professor
International College of Pharmaceutical Innovation
Email: danwu@suda.edu.cn; danwu@rcsi.com
Tel: 0512-65886007
Biography
Dr. Wu graduated from Donghua University in 2010 and received his PhD in Chemistry and Biochemistry from University College Dublin (UCD) in 2014. From 2015 to 2018, he was a postdoctoral research fellow in the Department of Chemistry at the Royal College of Surgeons in Ireland (RCSI). In 2019, he studied as a visiting scientist at the University of Edinburgh and Heriot-Watt University's Super-Resolution Imaging Centre (ESRIC). He then returned to RCSI as an honorary lecturer until 2023. Currently, Dr. Wu is a research lecturer and independent principal investigator (PI) at RCSI. He will also serve as professor at the International College of Pharmaceutical Innovation Soochow University, where he will lecture in pharmaceutical and medicinal chemistry for undergraduates and supervise postgraduate students. Dr. Wu’s research interests include:
1.Development of NIR fluorophore and PDT agents
2.Tetrazine chemistry
3.Fluorescence guided surgery
4.Super resolution fluorescence imaging and fluorescence lifetime imaging (FLIM)
5.Artificial intelligence (AI) chemistry reaction prediction
He has been awarded several research grants such as €550,000 from SFI, €124,000 from IRC, and €450,000 from HRB. Dr. Wu has published over 40 peer-reviewed research papers in top-tier chemistry journals, such as PNAS, Chem Sci, Theranostics, Chem Comm, Org Lett, Chem, Nature (Research Highlight), J. Med. Chem, Sci. Rep., and Pharmaceuticals etc.
Select Publications
27.Kishimoto, A., Wu, D.*, O’Shea, D., Forecasting vaping health risks through neural network model prediction of flavour pyrolysis reactions, Sci. Rep. 2024,14, 9591.
26.Wu, D., Durán-Sampedro, G., Fitzgerald, S., Garre, M., O’Shea, D., Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B-Free Bioorthogonal Imaging, Chem Comm. 2023, 59, 1951-1954.
25.Caulfield, C., Wu, D., O’Shea, D, et al. BF2-Azadipyrromethene Fluorophores for Intraoperative Vital Structure Identification. Molecules, 2023, 28(5), 2167.
24.Caulfield, C., O’Shea, D., Wu, D.* Dynamic Bioorthogonal Imaging using a Tetrazine NIR-AZA Fluorogenic Probe, Tetrahedron, 2023, 138, 133387.
23.Curtin, N., Garre, M., Wu, D., O’Shea D. Identifying STEDable BF2-Azadipyrromethene Fluorophores, Molecules, 2023, 28(3), 1415.
22.Caulfield, C., Wu, D., Garre M., O’Shea, D., Substituent Directed Cellular Imaging in the 800-850 nm range with BF2-Azadipyrromethene Fluorophores, RSC Advances 2023,13, 14963-14973.
21.Wu, D., Aonghusa, PM., O’Shea, DF., Correlation of national and healthcare workers COVID-19 infection data; implications for large-scale viral testing programs, Plos One 2021, 16 (4), e0250699.
20.Curtin, N., Wu, D., R Cahill, A Sarkar, P Mac Aonghusa, S Zhuk, M Barberio, Dual color imaging from a single BF2-Azadipyrromethene fluorophore demonstrated in vivo for lymph node identification. International journal of medical sciences 2021, 18 (7), 1541.
19.Wu, D.*, O'Shea, D.F. Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate. Proceedings of the National Academy of Sciences of the USA, 2020, 117 (12) 6349.
18.Daly, H.C., Conroy, E., Wu, D., Gallagher, W.M., O'Shea, D.F. An EPR strategy for bio-responsive fluorescence guided surgery with simulation of the benefit for imaging. Theranostics 2020; 10(7):3064.
17.Wu, D., O’Shea, D.F. Vaping additive yields an ‘exceptionally toxic’ by-product. Nature 579, 474 (2020) doi: https://doi.org/10.1038/d41586-020-00808-9 (research highlights)
16.Wu, D., Daly, H.C., Grossi, M., Conroy, E., Li, B., Gallagher, W.M., O'Shea, D.F. RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery. Chemical Science, 2019, 10, 6944.
15.Wu, D., Durán-Sampedro, G., O’Shea, D.F. Synthesis and properties of water soluble 1,9-dialkyl substituted BF2 azadipyrromethene (NIR-AZA) fluorophores. Frontiers of Chemical Science and Engineering, 2019,1-8.
14.Wu, D., Daly, H.C., Conroy, E., Li, B., Gallagher, W.M., Cahill, R.A., O'Shea, D.F. PEGylated BF2 azadipyrromethene (NIR-AZA) fluorophores for intraoperative imaging. European Journal of Medicinal Chemistry 2019, 161, 343.
13.Henari, F.Z., O’Shea, D., Wu, D., Nonlinear optical measurements of BF2 aza dipyrromethene fluorophores. Chemical Physics Letters: X, 2019, 100020.
12.Wu, D., Cheung, S., Sampedro, G., Chen, Z.-L., Cahill, R.A., O’Shea, D.F. A DIE responsive NIR-fluorescent cell membrane probe. BBA Biomembranes 2018, 1860, 2272.
11.Wu, D., D O'Shea, N Mulligan, E Loughman, HA Kockhar, R Cahill, Optical discrimination of primary colorectal cancer using systemic Indocyanine green with near-infrared laparoscopy and microscopy: clinical pilot experience, Irish Journal of medical science 2018,187, S159.
10.Monopoli, M.P., Zendrini, A., Wu, D., Cheung, S., Sampedro, G., Ffrench, B., Nolan, J., Piskareva, O., Stalings, R.L., Ducoli, S., Bergese, P., O’Shea, D.F. Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe. Chemical Communications 2018, 54, 7219.
9.Cheung, S., Wu, D., Daly, H., Busschaert, N.; Morgunova, M., Simpson, J., Scholz, D., Gale, P.A., O'Shea, D.F. Real-time recording of the cellular effects of the anion transporter prodigiosin. Chem 2018, 4, 879.
8.Kitteringham, E., Wu, D., Cheung, S., Twamley, B., O'Shea, D.F., Griffith, D.M. Development of a novel carboplatin like cytoplasmic trackable near infrared fluorophore conjugate via strain-promoted azide alkyne cycloaddition. Journal of Inorganic Biochemistry 2018, 182, 150.
7.Kaltner, H., Manning, J.C., Caballero, G.G., Di Salvo, C., Gabba, A., Romero-Hernandez, L.L., Knospe, C., Wu, D., Daly, H.C., O'Shea, D.F., Gabius, H.J., Murphy, P.V. Revealing bio-medically relevant cell and lectin type-dependent structure-activity profiles for glycoclusters by using tissue sections as an assay platform. RSC Advances 2018, 8, 28716.
6.Wu, D., O’Shea, D.F. Fluorogenic NIR-probes based on 1,2,4,5-tetrazine substituted BF2-azadipyrromethenes. Chemical Communications 2017, 53, 10804.
5.Wu, D., O’Shea, D.F. Comparative triad of routes to an alkyne-BF2 azadipyrromethene near-infrared fluorochrome. Tetrahedron Letters 2017, 58(47), 4468.
4.Wu, D., Cheung, S., O'Sullivan, C.J., Gao, Y.H., Chen, Z.L., O'Shea, D.F. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances 2016, 6, 87373.
3.Wu, D., Cheung, S., Devocelle, M., Zhang, L., Chen, Z.L., O’Shea, D.F. Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome. Chemical Communications 2015, 51, 16667.
2.Wu, D., Cheung, S., Daly, R., Burke, H., Scanlan, E.M., O’Shea, D.F. Synthesis and glycoconjugation of an azido BF2 azadipyrromethene near-infrared fluorochrome. European Journal of Organic Chemistry 2014, 6841.
1.Wu, D., O’Shea, D.F. Synthesis and Properties of BF2-3,3-Dimethyldiaryl azadipyrromethene near-infrared fluorophores. Organic Letters 2013, 15, 3392.
